| Actor | Personaje | Temporadas |
|---|---|---|
| Nina Dobrev | Elena Gilbert Katherine Pierce/Katerina Petrova |
1, 2, 3, 4, 5 |
| Paul Wesley | Stefan Salvatore/Silas | 1, 2, 3, 4, 5 |
| Ian Somerhalder | Damon Salvatore | 1, 2, 3, 4, 5 |
| Steven R. McQueen | Jeremy Gilbert | 1, 2, 3, 4, 5 |
| Candice Accola | Caroline Forbes | 1, 2, 3, 4, 5 |
| Zach Roerig | Matt Donovan | 1, 2, 3, 4, 5 |
| Michael Trevino | Tyler Lockwood | 1, 2, 3, 4, 5 |
| Joseph Morgan | Niklaus Mikaelson | 2, 3, 4, |
Secundarios
| Actor | Personaje | Temporadas |
|---|---|---|
| Marguerite MacIntyre | Sheriff Elizabeth Forbes | 1, 2, 3, 4,5 |
| Melinda Clarke | Kelly Donovan | 1 |
| Natashia Williams | Lucy Bennett | 2 |
| Daniel Gillies | Elijah Mikaelson | 2, 3, 4 |
| Claire Holt | Rebekah Mikaelson | 3, 4, |
| Torrey DeVitto | Meredith Fell | 3, 4 |
| Persia White | Abby Bennett Wilson | 3, 4 |
| Robert Ri’chard | Jamie | 3 |
| Grace Phipps | April Young | 4, 5 |
| Phoebe Tonkin | Hayley | 4 |
| Madeline Zima |
Charlotte | 4 |
| Rick Worthy |
Rudy Hopkins | 4, 5 |
| Raymond Scott Parks |
Silas (Alucinación deforme) | 4 |
| Daniella Pineda |
Sophie | 4 |
| Charles Michael Davis |
Marcel | 4 |
| Leah Pipes |
Camille | 4 |
| Olga Fonda |
Nadia | 5 |
| Kendrick Sampson |
Jesse | 5 |
| Janina Gavankar |
Tessa | 5 |
| Shaun Sipos |
Aaron | 5 |
Fallecidos
| Actor | Personaje | Temporadas |
|---|---|---|
| Bianca Lawson | Emily Bennett | 1 |
| Benjamin Ayres | William Tanner | 1 |
| Chris William Martin | Zach Salvatore | 1 |
| Chris J. Johnson | Logan Fell | 1 |
| Kayla Ewell | Vicki Donovan | 1, 2, 3 |
| Arielle Kebbel | Lexi | 1, 2, 3, 4 |
| Jasmine Guy | Sheila Bennett | 1, 3, 4 |
| Sean Faris | Ben | 1 |
| Kelly Hu | Pearl | 1, 3 |
| Sterling Sulieman | Harper | 1 |
| Malese Jow | Annabelle | 1, 2, 3 |
| Rob Pralgo | Alcalde Richard Lockwood | 1 |
| Taylor Kinney | Mason Lockwood | 2, 3 |
| Trent Ford | Trevor | 2 |
| Trevor Peterson | Slater | 2 |
| Lauren Cohan | Rosemary | 2, 3 |
| Stephen Amell | Brady | 2 |
| Bryton James | Luka Martin | 2 |
| Randy J. Goodwin | Dr. Jonas Martin | 2 |
| Mia Kirshner | Isobel Flemming-Saltzman | 1, 2 |
| Gino Anthony Pesi | Maddox | 2 |
| Michaela McManus | Jules | 2 |
| Sara Canning | Jenna Sommers | 1, 2, 3 |
| Lisa Tucker | Greta Martin | 2 |
| David Anders | Jonathan John Gilbert | 1, 2 |
| Dawn Olivieri | Andie Star | 2, 3 |
| David Gallagher | Ray Sutton | 3 |
| Charmin Lee | Gloria | 3 |
| Sebastian Roché | Mikael | 3 |
| Jack Coleman | Bill Forbes | 3 |
| Caspar Zafer | Finn Mikaelson | 3 |
| Cassidy Freeman | Sage | 3 |
| James MacDonald |
Grayson Gilbert | 3 |
| Erin Beute |
Miranda Sommers-Gilbert | 3, 4 |
| Alice Evans | Esther | 3 |
| Matthew Davis | Alaric Saltzman | 1, 2, 3, 4 |
| Michael Reilly Burke |
Pastor Young | 4 |
| Paul Telfer |
Alexander | 4 |
| Blake Hood |
Dean | 4 |
| Todd Williams |
Connor Jordan27 | 4 |
| Ser’Darius Blain |
Chris | 4 |
| Micah Parker |
Adrian | 4 |
| Alyssa Diaz15 | Kimberley | 4 |
| Susan Walters | Carol Lockwood | 1, 2, 3, 4 |
| Nathaniel Buzolic | Kol Mikaelson | 3, 4 |
| Camille Guaty |
Caitlin Shane | 4 |
| David Alpay |
Profesor Atticus Shane | 4 |
| Charlie Bewley |
Galen Vaughn | 4 |
| Cynthia Addai-Robinson |
Aja | 4 |
| Katerina Graham | Bonnie Bennett | 1, 2, 3, 4,5 |
The Vampire Diaries My Obsession 